Effect of Short-term Oxygen During CPET in HFpEF

University of Zurich (UZH)

Status: Completed

Conditions: Heart Failure, Diastolic (HFpEF)

Treatments: Procedure: Sham room air; Procedure: Oxygen application

Study type: Interventional

Funder types: Other

Identifiers

NCT04157660

KEK-ZH-NR. 2012-0251_3

Details and patient eligibility

About

In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with heart failure with preserved ejection fraction.

Enrollment: 10 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HFpEF, stable medication for at least 4 weeks.

Exclusion criteria

• instable status, pregnancy, clinically relevant concomitant diseases, inability to follow the study procedures

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups

Supplemental oxygen

Experimental group

Description:

Supplemental oxygen will be applied via a mask during CPET

Treatment:

Procedure: Oxygen application

Sham room air

Sham Comparator group

Description:

Room air will be applied similarly to oxygen

Treatment:

Procedure: Sham room air