ClinicalTrials.Veeva

Menu

Effect of Simultaneous Dual Stimulation on Freezing of Gait in Parkinson's Disease

Samsung Medical Center logo

Samsung Medical Center

Status

Completed

Conditions

Parkinson Disease

Treatments

Device: rTMS
Device: rTMS and tDCS

Study type

Interventional

Funder types

Other

Identifiers

NCT02850159
2013-09-122

Details and patient eligibility

About

The purpose of this study is to investigate the effect of dual-mode non-invasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson's disease (PD) with freezing of gait (FOG).

Full description

Patients in the dual-mode group underwent five consecutive daily sessions of dual-mode NIBS with simultaneous high-frequency rTMS and tDCS, whereas patients in the rTMS group underwent high-frequency rTMS with sham tDCS. Assessments of FOG, motor, ambulatory and cognitive function were performed three times: at baseline before NIBS, immediately after NIBS, and one week after cessation of NIBS.

Enrollment

32 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • diagnosed as Parkinson's disease (PD) with freezing of gait
  • walk independently without walking devices

Exclusion criteria

  • pre-existing and active major neurological diseases other than PD
  • a previous history of seizures
  • implanted metallic objects that would contraindicate rTMS

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

32 participants in 2 patient groups

dual-mode group
Experimental group
Description:
the dual-mode NIBS with high-frequency rTMS and tDCS simultaneously
Treatment:
Device: rTMS and tDCS
rTMS group
Active Comparator group
Description:
high-frequency rTMS and sham tDCS
Treatment:
Device: rTMS

Trial contacts and locations

0

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems