Effect of Simultaneous Dual Stimulation on Freezing of Gait in Parkinson's Disease

Samsung Medical Center

Status: Completed

Conditions: Parkinson Disease

Treatments: Device: rTMS; Device: rTMS and tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02850159

2013-09-122

Details and patient eligibility

About

The purpose of this study is to investigate the effect of dual-mode non-invasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson's disease (PD) with freezing of gait (FOG).

Full description

Patients in the dual-mode group underwent five consecutive daily sessions of dual-mode NIBS with simultaneous high-frequency rTMS and tDCS, whereas patients in the rTMS group underwent high-frequency rTMS with sham tDCS. Assessments of FOG, motor, ambulatory and cognitive function were performed three times: at baseline before NIBS, immediately after NIBS, and one week after cessation of NIBS.

Enrollment: 32 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed as Parkinson's disease (PD) with freezing of gait
• walk independently without walking devices

Exclusion criteria

• pre-existing and active major neurological diseases other than PD
• a previous history of seizures
• implanted metallic objects that would contraindicate rTMS

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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32 participants in 2 patient groups

dual-mode group

Experimental group

Description:

the dual-mode NIBS with high-frequency rTMS and tDCS simultaneously

Treatment:

Device: rTMS and tDCS

rTMS group

Active Comparator group

Description:

high-frequency rTMS and sham tDCS

Treatment:

Device: rTMS