Effect of Sleep Debt on Neurophysiological Responses to Heat Exposure (ChaSPerf)

Direction Centrale du Service de Santé des Armées

Status: Enrolling

Conditions: Heat; Excess; Sleep Disorder

Treatments: Other: Sleep restriction; Other: Sleep recording (at home); Other: Normal sleep; Other: Heat exposure

Study type: Observational

Funder types: Other

Identifiers

NCT05181345

2021PBMD05

2021-A02278-33 (Other Identifier)

Details and patient eligibility

About

Many people are required to work in stressful situations combining sleep debt and hot environmental conditions. If the effect of sleep debt on cognitive performance is proven, this effect could be increased, during heat exposure, through the deleterious effects of sleep debt on thermoregulatory abilities. These alterations may favour the occurrence of accidents.

The changes in cognitive performance induced by hyperthermia are also poorly characterised and often not dissociated from the effects of dehydration. Little is known about the effects of the combination of sleep debt and heat exposure on mental performance. Describing and understanding the alterations induced by this combined situation could provide a better understanding of the mechanisms explaining the deterioration of performance in hot conditions and promote the development of appropriate countermeasures.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 35 years old
• Body Mass Index between 18 and 27 kg/m2
• Body weight ≥ 54 kg

Exclusion criteria

• Presence or history of medical pathology (cardiological, renal, hepatic, cutaneous, intestinal, neurological...)
• Presence of a significant deviation from the normal values observed on the electrocardiogram
• History of heat stroke
• Known intolerance to heat (e.g. migraine sufferers)
• Presence of a contraindication to blood sampling, notably low venous capital, belonephobia
• Inability to ingest a capsule or refusal of the rectal probe
• Habitual consumption of caffeine > 500 mg per day
• Alcohol consumption greater than the equivalent of 3 glasses of wine per week
• Consumption of narcotics
• Smoking > 0.5 packet of cigarettes per day
• Undergoing habitual medication
• Pregnant or breastfeeding woman

Trial design

20 participants in 2 patient groups

Normal sleep first

Description:

The night before the first heat exposure, the participants will have a normal night at home. The night before the second heat exposure, the participants sleep will be restricted to 3 hours in bed.

Treatment:

Other: Sleep restriction

Other: Sleep recording (at home)

Other: Normal sleep

Other: Heat exposure

Reduced sleep first

Description:

The night before the first heat exposure, the participants sleep will be restricted to 3 hours in bed. The night before the second heat exposure, the participants will have a normal night at home.

Treatment:

Other: Sleep restriction

Other: Sleep recording (at home)

Other: Normal sleep

Other: Heat exposure