Effect of Smoking Cessation on Glycemic Control in Type 2 Diabetics

Assiut University

Status: Not yet enrolling

Conditions: Smoking Cessation

Treatments: Behavioral: Smoking cessation counselling group

Study type: Observational

Funder types: Other

Identifiers

NCT06687213

Smoking cessation and HbA1C

Details and patient eligibility

About

The goal of this observational study is to learn about the long-term effects of smoking cessation on glycemic control in type 2 diabetic patients The main question it aims to answer is:

Does smoking cessation lower HbA1c in type 2 diabetics on long term ? The participants will be counseled to cessate smoking and will be followed for 6 months and compared to control who will not cessate smoking .

Full description

Smoking and diabetes are both major public health issues specially in our community. They act synergistically on morbidity and mortality. Diabetic smokers have much higher rates of micro and macrovascular complications. [Carole Clair et al., 2020] Approximately 1.3 billion people worldwide use tobacco, most commonly in the form of tobacco smoking, and more than 7 million people die every year as a result of smoking related conditions [Magdalena Walicka et al.,2022] Exposure to cigarette smoke is associated with vascular damage, endothelial dysfunction, and activation of oxidative stress, inflammatory pathways, coagulation, and fibrinolysis A similar mechanism of endothelial dysfunction is described for people with diabetes. It is therefore not surprising that smoking enhances the combined harmful effects of elevated blood glucose levels, accelerating vascular damage in diabetic patients who smoke The prevalence of current smoking was 45.5% in male patients with type 2 diabetes. The levels of fasting blood glucose and HbA1c increased with number of cigarettes smoked per day compared with non-smokers Smoking and its cessation showed dose- and time-dependent relationship with glycemic control and insulin resistance in patients with type 2 diabetes mellitus. These findings may highlight the importance of smoking cessation in the clinical management of diabetes mellitus.

the effect of smoking and its cessation on glycemic control in diabetic patients has not been fully examined yet.

There is lack of evidence regarding interventions for smoking cessation among individuals with diabetes

Enrollment: 178 estimated patients

Sex: All

Ages: 35 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Moderate Somking index Having been diagnosed with a type 2 diabetes Being ≥ 35 years old HbA1c > 7

Exclusion criteria

Type 1 diabetes Drug induced Diabetes mellitus Type 2 diabetes on insulin treatment

Trial design

178 participants in 2 patient groups

1_Case group 2_control group

Description:

1. Case group diabetic smokers which will be counseled to cessate smoking 2. Control group diabetic smokers which will refuse to cessate smoking

Treatment:

Behavioral: Smoking cessation counselling group

Case control group

Description:

Case group: diabetic smokers which will cessate smoking Control group: diabetic smokers which will refuse to cessate smoking