Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy

October 6 University

Status: Completed

Conditions: Periodontal Diseases; Smoking Cessation

Treatments: Procedure: Conventional non-surgical periodontal therapy; Procedure: Minimally invasive non-surgical periodontal therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06145685

12-2014 OMD

Details and patient eligibility

About

The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease. This is to assess the period of smoking abstinence needed before any periodontal surgery in order to reverse the negative effects of the reported increased levels of inflammatory markers (IL-1β and PGE2 in this study) associated with smoking on the healing and the periodontium.

Enrollment: 40 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with advanced chronic periodontitis upon clinical examination with clinical attachment loss (CAL) more than 5 mm.
• Patients willing to quit smoking to be included in two groups, while patients unwilling to quit smoking to be included in the third group, and the non-smokers as the fourth group.

Exclusion criteria

• Any systemic illness known to affect the outcome.
• Systemic antimicrobial or anti-inflammatory drug therapy within the last 3 months prior to the study.
• Patients unable to perform routine oral hygiene procedures.
• Patients using other forms of tobacco.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 4 patient groups

Previous smokers - Minimally invasive

Active Comparator group

Description:

Minimally invasive non-surgical periodontal treatment

Treatment:

Procedure: Minimally invasive non-surgical periodontal therapy

Previous smokers - Conventional

Active Comparator group

Description:

Conventional non-surgical periodontal treatment

Treatment:

Procedure: Conventional non-surgical periodontal therapy

Smoker

Active Comparator group

Description:

Conventional non-surgical periodontal treatment

Treatment:

Procedure: Conventional non-surgical periodontal therapy

Non-smoker

Active Comparator group

Description:

Conventional non-surgical periodontal treatment

Treatment:

Procedure: Conventional non-surgical periodontal therapy