Effect of Smoking on Saliva Composition and the Development of Dental Erosion

University of Göttingen

Status

Completed

Conditions

Dental Erosion

Treatments

Other: Use of fluoridated toothpaste

Other: Wearing of an intraoral device with resin samples

Other: Wearing of an intraoral device with bovine tooth samples

Study type

Observational

Funder types

Other

Identifiers

NCT04208802

02785 (Other Identifier)

15/10/19 (Other Identifier)

Erosion-Smoking

Details and patient eligibility

About

The aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion.

Healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. Afterwards, specimens are eroded extraorally and calcium release into the acid is measured.

Total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. Additionally, salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.

Enrollment

50 patients

Sex

All

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Volunteers aged between 20 and 50 years who are able to give written consent

Exclusion criteria

Non-fulfillment of the inclusion criteria
Intake of medications or diseases altering salivary secretion
Refusal to use fluoridated toothpastes
Known allergies to substances used in the study
Orthodontic treatment or malfunction which does not allow wearing an intraoral device