Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis

Masoud Saatchi

Status and phase: Completed; Phase 3

Conditions: Local Anesthesia

Treatments: Drug: placebo; Drug: sodium bicarbonate; Drug: 2% lidocaine with 1:80,000 epinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT02226913

193396

Details and patient eligibility

About

Buffering of local anesthetics (alkalinization) has been suggested in achieving pain control. The purpose of this prospective, randomized, double-blind study was to evaluate the effect of adding 0.6 mL 8.4% sodium bicarbonate to 3.0 mL 2% lidocaine with 1: 80,000 epinephrine on the success rate of IAN block for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

Full description

Some studies have been shown buffering of local anesthetics reduce pain of injection, hasten the onset of anesthesia, and improved success rate of anesthesia. Others reported buffering of local anesthetics cannot reduce pain of injection, hasten the onset of anesthesia, and improve success rate of anesthesia. There are no studies evaluating a sodium bicarbonate-buffered lidocaine formulation for IAN block for teeth with irreversible pulpitis.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• vital mandibular molar tooth
• diagnosis of symptomatic irreversible pulpitis

Exclusion criteria

• younger than 18 years old
• history of significant medical conditions
• allergies to local anesthetics or sulfites
• pregnancy
• taking any medications that might influence anesthetic assessment
• active sites of pathosis in area of injection
• inability to give informed consent

Trial design

80 participants in 2 patient groups

lidocaine & sodium bicarbonate

Experimental group

Description:

2% lidocaine with 1: 80,000 epinephrine buffered with 0.18 mL of 8.4% sodium bicarbonate

Treatment:

Drug: 2% lidocaine with 1:80,000 epinephrine

Drug: sodium bicarbonate

lidocaine & placebo

Active Comparator group

Description:

2% lidocaine with 1:80,000 epinephrine with 0.18 mL of sterile distilled water

Treatment:

Drug: 2% lidocaine with 1:80,000 epinephrine

Drug: placebo