Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis

Yonsei University

Status

Completed

Conditions

Recurrent Aphthous Stomatitis

Treatments

Other: sodium lauryl sulfate

Study type

Interventional

Funder types

Other

Identifiers

NCT01501409

2-2009-0012

Details and patient eligibility

About

Sodium lauryl sulfate (SLS) is an anionic detergent that has been used as the major or sole surfactant in most dentifrices. But it is known to local irritating factor to oral mucosa and skin and results in many side effects. This study was to compare the effects of SLS-free dentifrice and SLS-containing dentifrice in patients with recurrent aphthous stomatitis (RAS).

Enrollment

90 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

The volunteers had a history of regularly recurring oral ulcerations of at least 6 months duration, with more than one episode per month

Exclusion criteria

already using an SLS-free dentifrice
taking medications affecting oral ulcers (e.g., corticosteroids)
having chronic oral mucosal disease (ex, lichen planus, pemphigus vulgaris, pemphigoid, and etc.)
having allergies to food or medications
being pregnant