Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation During Knee Surgery With Pneumatic Tourniquet

University of Liege

Status: Completed

Conditions: Knee Surgery With Tourniquet

Treatments: Drug: Bupivacaine / SUFentanil; Drug: Sevoflurane Volatile Liquid

Study type: Interventional

Funder types: Other

Identifiers

NCT03470363

456

Details and patient eligibility

About

Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia

Full description

Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia This activation was assessed by plasma myeloperoxidase and elastase measurements in four consecutive blood samples during and after surgery (before surgical incision and 1, 3, 24 hours following tourniquet release.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Total knee arthroplasty under spinal or sevoflurane anesthesia

Exclusion criteria

• American Society of Anesthesiologists class 3 and 4
• vascular disease of the lower limbs
• cardiac or respiratory disease
• immune disorder

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Group Spinal anesthesia

Active Comparator group

Description:

Knee surgery under spinal anesthesia Intervention involves spinal administration of 12,5 mg bupivacaine and 2,5 microgram sufentanil.

Treatment:

Drug: Bupivacaine / SUFentanil

Group Sevoflurane anesthesia

Active Comparator group

Description:

Knee surgery under sevoflurane anesthesia Intervention involves administration of inhaled sevoflurane for maintenance of general anesthesia

Treatment:

Drug: Sevoflurane Volatile Liquid