Effect of Standard Care Rehabilitation Versus Interval Treadmill Training After Myocardial Infarction

Norwegian University of Science and Technology

Status: Completed

Conditions: Myocardial Infarction

Treatments: Behavioral: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT00235339

MI-05-01

Details and patient eligibility

About

The purpose of this study is to investigate the effect of the standard rehabilitation offered by three hospital rehabilitation units in Norway, one in Trondheim, one in Ålesund and one in Levanger, compared to an interval treadmill training program. The subjects participating in the study are patients with myocardial infarction. The maximal oxygen consumption of the subjects will be tested before and after the training period.

Full description

The purpose of this study is to investigate the effect of the standard rehabilitation offered by three hospital rehabilitation units in Norway, one in Trondheim, one in Ålesund and one in Levanger, compared to an interval treadmill training program. The subjects participating in the study are patients with myocardial infarction. The maximal oxygen consumption of the subjects will be tested before and after the training period.

Primary outcome: Maximal oxygen consumption Secondary outcomes: Blood values (for endothelial function, blood lipids, etc), flow mediated dilatation, quality of life (SF 36 and MacNew), weight, BMI, heart rate fall 1 minute after stopping the maximal treadmill test.

Enrollment: 89 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Myocardial infarction 2-12 weeks ago

Exclusion criteria

• Heart failure
• limitations to walking on a treadmill
• failure to reach a maximal pre-test(> NYHA class II)
• uncontrolled hypertension
• COPD
• pregnancy
• kidney failure (creatinin > 140)
• drug abuse
• left ventricle EF < 30%

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

89 participants in 2 patient groups

1

Active Comparator group

Description:

Standard exercise training rehabilitation at the hospital

Treatment:

Behavioral: Exercise training

Behavioral: Exercise training

2

Experimental group

Description:

Interval exercise training on treadmills, with high intensity

Treatment:

Behavioral: Exercise training

Behavioral: Exercise training