Effect of Stellate Ganglion Block on Meniere's Disease

Chi Mei Medical Foundation

Status and phase: Completed; Phase 4

Conditions: Vertigo; Meniere Disease

Treatments: Drug: 200mg kentons@ (tocopherol nicotinate).; Drug: 25mg cephadol@ (diphenidol); Procedure: stellate ganglion block; Drug: 0.25mg, fludiazine

Study type: Interventional

Funder types: Other

Identifiers

NCT01574313

CMH09804-003 (Other Grant/Funding Number)

SGB09804-003

Details and patient eligibility

About

Stellate ganglion block (SGB) has been the alternative treatment of Meniere's disease for years. However, objective evidence of the effect of SGB was still lack. The investigators conducted a randomized controlled study to examine the immediate effects of SGB in SP/AP of electrocochleography (ECoG).

Full description

Ten patients were randomly assigned to receive stellate ganglion block. These ten patients made up the experimental group. Another ten patients in the control group were assigned to receiving one dosage of oral medications: 0.25mg of erispan@ (fludiazine) , 25mg cephadol@ (diphenidol), and 200mg kentons@ (tocopherol nicotinate).

Enrollment: 20 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with unilateral Meniere's disease, according to the criteria of the American Academy of Otolaryngology-Head and Neck Surgery, AAO-HNS (1995)

Exclusion criteria

• patients with coagulopathy,
• arrhythmia,
• myocardial ischemia,
• glaucoma,
• pregnant,
• chronic otitis media or externa, and
• past history of middle or inner ear surgery were excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Stellate ganglion block

Experimental group

Description:

treated with SGB

Treatment:

Procedure: stellate ganglion block

Oral medication

Active Comparator group

Description:

treated with oral medications: 0.25mg of erispan@ (fludiazine) , 25mg cephadol@ (diphenidol), and 200mg kentons@ (tocopherol nicotinate).

Treatment:

Drug: 0.25mg, fludiazine

Drug: 25mg cephadol@ (diphenidol)

Drug: 200mg kentons@ (tocopherol nicotinate).