Effect of Stimulant Drugs on Social Perception (ESP)

The University of Chicago

Status and phase: Completed; Phase 1

Conditions: Healthy; MDMA ('Ecstasy')

Treatments: Drug: 3,4-Methylenedioxymethamphetamine; Drug: methamphetamine

Study type: Interventional

Funder types: Other

Identifiers

NCT03790618

IRB15-780

Details and patient eligibility

About

The study will improve our understanding of the "prosocial" effects of ± 3,4-Methylenedioxymethamphetamine (MDMA), relative to a prototypical stimulant, methamphetamine (MA). The investigators seek to characterize the "uniquely social" effects of MDMA.

Enrollment: 36 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• High school degree
• English fluency
• Healthy
• Has used MDMA

Exclusion criteria

• Pregnant or trying to become pregnant
• Any medical or psychiatry condition

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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36 participants in 4 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Subjects will attend one session during which they will receive a placebo capsule.

Treatment:

Drug: methamphetamine

Drug: 3,4-Methylenedioxymethamphetamine

Low dose MDMA

Experimental group

Description:

Subjects will attend one session during which they will receive 0.75mg/kg MDMA.

Treatment:

Drug: methamphetamine

Drug: 3,4-Methylenedioxymethamphetamine

High dose MDMA

Experimental group

Description:

Subjects will attend one session during which they will receive 1.5mg/kg MDMA.

Treatment:

Drug: methamphetamine

Drug: 3,4-Methylenedioxymethamphetamine

Methamphetamine

Experimental group

Description:

Subjects will attend one session during which they will receive 20mg methamphetamine.

Treatment:

Drug: methamphetamine

Drug: 3,4-Methylenedioxymethamphetamine