Effect of Stress on Heroin-Related Memory Retrieval

National Institute on Drug Dependence, China

Status: Completed

Conditions: Learning and Memory; Heroin Dependence

Treatments: Drug: propranolol and cortisol

Study type: Interventional

Funder types: Other

Identifiers

NCT00759005

NIDD

Details and patient eligibility

About

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Sex: Male

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion criteria

• current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Trial design

0 participants in 1 patient group

A, 4

Experimental group

Treatment:

Drug: propranolol and cortisol