Effect of Sulfur Thermal Water on Circulating H2S Levels and Markers of Bone Metabolism in Osteopenic Subjects. (FORST3)

Istituto Ortopedico Rizzoli

Status: Completed

Conditions: Osteoporosis; Hydrogen Sulfide

Treatments: Other: inhalatory treatment with sulfureous aerosol

Study type: Interventional

Funder types: Other

Identifiers

NCT06095349

FORST3

Details and patient eligibility

About

The aim of the study is to investigate whether inhalation treatment with high-sulfide waters from some spas (referred to as "thermal waters"), performed for 12 consecutive days, is able to change circulating H2S levels and alter bone metabolism. Identifying a clear correlation between circulating levels of H2S and sulfur water administration, as well as a potential anabolic effect on bone, would set the stage for new studies that could have important clinical implications for promoting health and preventing osteoporosis

Enrollment: 50 patients

Sex: Female

Ages: 50 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• post-menopausal women with a diagnosis of osteopenia

Exclusion criteria

• concurrent muscoloskeletal conditions or chronic pharmacological treatment interfering with bone metabolism

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Bone turnover markers

Experimental group

Description:

Concentrations of bone turnover markers will be assessed before and after treatment. Correlation will be sought for with H2S levels and clinical features of the patients

Treatment:

Other: inhalatory treatment with sulfureous aerosol