Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes (SURF)

University Hospital, Angers

Status: Enrolling

Conditions: Importance of Interictal Epileptiform Activity on Sleep EEG; Epilepsy in Children

Treatments: Drug: Sulthiame

Study type: Observational

Funder types: Other

Identifiers

NCT05885646

49RC23_0073

Details and patient eligibility

About

The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.

Enrollment: 15 estimated patients

Sex: All

Ages: 6 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of epilepsy syndromes of childhood with sleep activation
• Failure of at least two anti-epileptic drugs (AED)
• Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG)

Exclusion criteria

• Previous trial with sulthiame
• More than 2 AED at inclusion
• Use of corticosteroids at inclusion
• Change in the anti-epileptic treatment in the 7 days before baseline EEG