Effect of Supplementation of Bioactive Compounds on the Energy Metabolism of People Living With HIV / AIDS

Universidade Federal do Rio Grande do Norte

Status: Completed

Conditions: HIV Infections

Treatments: Dietary Supplement: Curcumin; Other: Placebo of Curcumin

Study type: Interventional

Funder types: Other

Identifiers

NCT03141918

COMPOSTOS_BIOATIVOS_VIVER MAIS

Details and patient eligibility

About

Among the many changes associated with the impact of HIV and the long-term use of antiretroviral therapy, metabolics are important because they are important risk factors for the development of cardiovascular diseases. The objective of the present study is to evaluate the effect of the supplementation of curcumin, on the oxidation of resting energetic substrates in HIV / AIDS patients. The sample will be composed of adults living with HIV / AIDS on antiretroviral therapy for at least 6 months. Supplements will be made separately for 30 days and will be evaluated before and after the intervention the following parameters: body composition, energy metabolism, biochemical parameters and a structured anamnesis. Food consumption and the level of physical activity of the volunteers will be controlled.

Full description

The study is characterized as a double-blind randomized clinical trial. Participants in the study will be adults living with HIV / AIDS who undergo regular clinical follow-up at some Specialized HIV / AIDS Care Service.

The sample will consist of 20 volunteers, 10 in the experimental group (GE) and 10 in the control group (CG). Participants will be randomly assigned to one of the groups by lottery by a researcher not participating in the study. The researcher responsible, as well as the volunteers, will not be aware of which participants are in the GE or the GC.

The study will be carried out in the Movement Laboratory of the Physical Education Department of the Federal University of Rio Grande do Norte.

Enrollment: 20 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Antiretroviral therapy has been available for at least 6 months, aged 18 years or over.

Exclusion criteria

• Individuals with endocrine and pregnant disorders will be excluded.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

Curcumin group 1

Experimental group

Description:

Intervention will be with intake of curcumin, 1000mg per 30 days

Treatment:

Dietary Supplement: Curcumin

Curcumin group 2

Placebo Comparator group

Description:

Intervention will be with placebo intake of curcumin, 1000mg per 30 days

Treatment:

Other: Placebo of Curcumin