Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

Hacettepe University

Status: Completed

Conditions: Aggressive Periodontitis; Chronic Periodontitis; RANKL/OPG Ratio; Gingival Crevicular Fluid

Study type: Observational

Funder types: Other

Identifiers

NCT02190773

RANKL

Details and patient eligibility

About

In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

Enrollment: 65 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.

Exclusion criteria

• Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.

Trial design

65 participants in 3 patient groups

Chronic periodontitis

Description:

Surgical periodontal treatment and GCF collection 3 months after treatment

Agressive periodontitis

Description:

Surgical periodontal treatment and GCF collection 3 months after treatment.

Control group

Description:

Periodontally healthy individuals