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Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

H

Hacettepe University

Status

Completed

Conditions

Aggressive Periodontitis
Chronic Periodontitis
RANKL/OPG Ratio
Gingival Crevicular Fluid

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

Enrollment

65 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.

Exclusion criteria

  • Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.

Trial design

65 participants in 3 patient groups

Chronic periodontitis
Description:
Surgical periodontal treatment and GCF collection 3 months after treatment
Agressive periodontitis
Description:
Surgical periodontal treatment and GCF collection 3 months after treatment.
Control group
Description:
Periodontally healthy individuals

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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