Effect of SVV Guided Fluid Therapy on Blood Loss and Postoperative Outcomes

Asan Medical Center

Status: Completed

Conditions: Bladder Cancer

Treatments: Other: mannitol; Other: crystalloid; Other: colloid; Other: lasix

Study type: Interventional

Funder types: Other

Identifiers

NCT02373735

S2014-2192

Details and patient eligibility

About

The purpose of this study is to investigate the effect of stroke volume variation (SVV) guided fluid therapy on the blood loss and postoperative outcomes in radical cystectomy.

Full description

The purpose of this study is to investigate the effect of stroke volume variation(SVV) guided fluid therapy on the blood loss and postoperative outcomes in radical cystectomy. Patients were randomized to fluid management to maintain <10% SVV (group A), or to undergo fluid management during radical cystectomy to maintain SVV 10-20% (group B). Intraoperative blood loss and hemodynamic parameters, perioperative laboratory data, and postoperative complications were compared between two groups.

Enrollment: 64 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Bladder cancer patients who received radical cystectomy
• Patients with American Society of Anesthesiologists physical status scale classification 1, 2
• Patients who agree with written informed consent

Exclusion criteria

• Patients with history of arrhythmia, heart failure patients
• Patients with history of renal failure patients
• Patients with history of abdominal surgery
• Patients who received emergency operation
• Patients who do not agree with study

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 2 patient groups

Group A (SVV <10% group)

Active Comparator group

Description:

* infuse crystalloid (Hartmann's solution) 6-10 ml/kg/hr continuously during surgery * infuse colloid (Volulyte) 200 ml if SVV is ≥ 10% during the surgery Interventions: crystalloid (Hartmann's solution), colloid (Volulyte)

Treatment:

Other: crystalloid

Other: colloid

Group B (SVV 10-20% group)

Experimental group

Description:

* infuse crystalloid (Hartmann's solution) 2-4 ml/kg/hr until cystectomy, 6-10 ml/kg/hr after cystectomy * infuse colloid (Volulyte) 200 ml if SVV is \> 20% * infuse mannitol 0.5 g/kg or lasix 5 mg if SVV \< 10% Interventions: crystalloid (Hartmann's solution), colloid (Volulyte), mannitol, lasix

Treatment:

Other: lasix

Other: crystalloid

Other: mannitol

Other: colloid