Effect of Sweetness Intensity of a Sucrose Solution on Blood Glucose Regulation and Energy Intake

University of Vienna

Status and phase: Completed; Early Phase 1

Conditions: Blood Glucose, Low; Hunger

Treatments: Drug: Rebaudioside M; Other: Sucrose; Drug: Lactisole

Study type: Interventional

Funder types: Other

Identifiers

NCT04991714

706014-1

Details and patient eligibility

About

The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger & satiety.

Full description

The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• healthy
• non-smoking
• normal taste responses towards sweet taste

Exclusion criteria

• female
• regular smokers
• disturbed glucose and/or lipid metabolism
• regular intake of medication
• known allergies against one of the test compounds
• ageusia
• alcohol or drug addiction
• intake of antibiotics within the past 2 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

30 participants in 4 patient groups

Sucrose

Experimental group

Description:

10% solution in water

Treatment:

Other: Sucrose

Sucrose + Reb M

Experimental group

Description:

10% sucrose + 60 mg/L Rebaudioside M

Treatment:

Other: Sucrose

Drug: Rebaudioside M

Sucrose + Lactisole

Experimental group

Description:

10% sucrose + 30 mg/ L Lactisole

Treatment:

Drug: Lactisole

Other: Sucrose

Sucrose + Reb M + Lactisole

Experimental group

Description:

10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole

Treatment:

Drug: Lactisole

Other: Sucrose

Drug: Rebaudioside M