Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes

Beni-Suef University

Status and phase: Not yet enrolling; Phase 3; Phase 2

Conditions: IVF

Treatments: Drug: pentoxifylline; Drug: Sildenafil; Drug: tadalafil

Study type: Interventional

Funder types: Other

Identifiers

NCT05971667

Tadalafil IVF

Details and patient eligibility

About

The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated

Full description

A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups.

The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.

Enrollment: 200 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women having thawed embryos

Exclusion criteria

• hypotension
• cardiovascular, hepatic, and renal diseases;
• uncontrolled diabetes mellitus;
• ovarian cysts;
• hyperprolactinemia;
• abnormal thyroid functions;
• uterine fibroids;
• patients taking nitrates;
• endometriosis and adenomyosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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200 participants in 4 patient groups

tadalafil

Experimental group

Description:

tadalafil 10 mg one tablet daily

Treatment:

Drug: tadalafil

pentoxifylline

Experimental group

Description:

pentoxyfilline 400 mg two tabs daily

Treatment:

Drug: pentoxifylline

sildenafil

Experimental group

Description:

sildenafil 20 mg two tablets

Treatment:

Drug: Sildenafil

control group.

No Intervention group

Description:

no intervention is given