Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction

Tabriz University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Neurogenic Bladder

Treatments: Drug: prazosin; Drug: tamsolusin

Study type: Interventional

Funder types: Other

Identifiers

NCT00602186

85-1

Details and patient eligibility

About

The purpose of this study is to determine whether Tamsolusin or Prazosin are effective in the treatment of female voiding dysfunction(BOO)

Full description

Voiding dysfunction is not uncommon in Tabriz.About 20% of patients in female urology clinic of Tabriz university of medical sciences sufered from some degrees of voiding dysfunction (due to bladder imparement or bladder outlet obstruction).There is limited information about medical treatment of those patients. On the other hand alpha adrenergic blockers are the first choice medication in BENIGN PROSTATIC HYPERPLASIA. There is some new facts about destribution of alpha adrenergic blockers in female pelvic floor.The purpose of this study is to comparision whether Tamsolusin 0.4/daily or Prazosin 1 mg/daily are effective in the treatment of female voiding dysfunction(BOO)

Enrollment: 80 patients

Sex: Female

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy females with voiding difficulty with MFR<12 and post void residual urine>50cc

Exclusion criteria

• History of pelvic floor surgury during last 3 month
• Any contraindication for Tamsolusin or prazosin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

1

Experimental group

Description:

taking Tamsulosin

Treatment:

Drug: tamsolusin

2

Active Comparator group

Description:

taking prasosin

Treatment:

Drug: prazosin