Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.

Institute of Liver and Biliary Sciences, India

Status and phase: Enrolling; Phase 3; Phase 2

Conditions: Liver Transplant Recipients

Treatments: Drug: Target control infusion propofol; Drug: Inhalational isoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT06418893

IEC/2023/100/MA05

Details and patient eligibility

About

Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:-Above 18 years of age who will undergo living donor liver transplant

Exclusion Criteria: Refusal to consent

• Acute liver failure, Acute on chronic liver failure
• Allergic to propofol or any component of propofol
• Patients with pre existing cardiac dysfunction and cardiomyopathy
• Patients with pre existing renal dysfunction/ deranged RFTs preoperatively

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Isoflurane

Active Comparator group

Description:

Drug- Isoflurane Dosage form- Inhalational, 1-2% Frequency- Continuously Duration- Throughout Intraoperative period

Treatment:

Drug: Inhalational isoflurane

Propofol

Experimental group

Description:

Drug- Propofol Dosage form- Intravenously, 2.5 mcg/ml target plasma concentration Frequency- Continuously Duration- Throughout Intraoperative period

Treatment:

Drug: Target control infusion propofol