Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation

Capital Medical University

Status: Enrolling

Conditions: Intraoperative Hypotension; Kidney Transplant; Delayed Graft Function

Treatments: Drug: terlipressin

Study type: Interventional

Funder types: Other

Identifiers

NCT06855758

2025-P2-023-01

Details and patient eligibility

About

Prospective double blind randomized controlled trial. By randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed dobutamine group, the investigators compared the effect of intraoperative blood pressure maintenance and the dosage of the vasoactive drug, postoperative graft function, delayed graft function, and other related complications between the two groups, in order to demonstrate whether the use of terlipressin for blood pressure regulation during kidney transplantation is superior to the existing treatments.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with end-stage renal disease aged 18 years or above

Exclusion criteria

• simultaneous multiple organ transplantation
• known allergy to study medication
• known pregnancy status
• cancellation of surgery due to grafts or personal reasons
• persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications
• any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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150 participants in 2 patient groups

dopamine

No Intervention group

Description:

Continuous using of dopamine as blood pressure regulation after anesthesia, with dosage adjusted according to intraoperative needs

terlipressin + dopamine

Experimental group

Description:

Terlipressin was given before the graft circulation was established while continuous using of dopamine during the whole operation

Treatment:

Drug: terlipressin