Effect of the Addition of Dexmedetomidine to Bupivacaine During Supraclavicular Brachial Plexus Blockade

TC Erciyes University

Status and phase: Completed; Phase 4

Conditions: Sequelae of Fracture of Forearm and Upper Arm

Treatments: Drug: bupivacaine; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02049970

2013/107

Details and patient eligibility

About

the aim of this study was effect of the addition of dexmedetomidine to bupivacaine during supraclavicular brachial plexus blockade for forearm surgery, by low doses bupivacaine providing prolonged analgesia after surgery.

Full description

Anaesthesia for surgeries to the upper extremity commonly is provided using brachial plexus anaesthesia.Various local anaesthetic mixtures can be used to prolong local anaesthesia duration and epinephrine , opioids and dexmedetomidine are frequently used for this purpose. this study was conducted to compare the effects of adding dexmedetomidine to local anaesthetics in the supraclavicular brachial plexus block by using nerve stimulators and ultrasonography guided. dexmedetomidine has also been found the prolong the duration of bupivacaine infraclavicular brachial plexus block.

Enrollment: 44 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 age
• unwanted general anaesthesia
• ASA 1-2
• single forearm, arm surgery

Exclusion criteria

• major psychiatric problems
• major neurologic deficits
• coagulopathy
• drug allergies
• chronic analgesic used

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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44 participants in 2 patient groups

dexmedetomidine and bupivacaine

Experimental group

Description:

Bupivacaine 50 mg and dexmedetomidine 1 microgram/kg

Treatment:

Drug: dexmedetomidine

Drug: bupivacaine

Bupivacaine and placebo

Experimental group

Description:

Bupivacaine 100 mg and SF 10 ml

Treatment:

Drug: dexmedetomidine

Drug: bupivacaine