Effect of the Enteric Hormone Glucagon-Like Peptide (GLP-2) on the Intestinal Blood Flow in Patients With Short Bowel Syndrome

Glostrup University Hospital, Copenhagen

Status: Unknown

Conditions: Short Bowel Syndrome

Treatments: Drug: Placebo; Drug: GLP-2

Study type: Interventional

Funder types: Other

Identifiers

NCT00673751

H-A-2008-032

Details and patient eligibility

About

The aim of the study is to investigate the effect of the enteric hormone Glucagon-like Peptide (GLP-2) on patients with short bowel syndrome

Full description

previous studies have shown that GLP-2 increases mesenteric blow flow, we wish to examine the effect of subcutaneus GLP-2 on patients with short bowl syndrome. The patients will single blinded been given 450 nmol GLP-2 and isotonic saline in order to act as their own reference.

Enrollment: 8 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnose of short bowel syndrome 4 month of stable fase

Exclusion criteria

• activity in IBD

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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8 participants in 2 patient groups, including a placebo group

2

Placebo Comparator group

Description:

subcutaneous isotonic saline

Treatment:

Drug: Placebo

1

Active Comparator group

Description:

subcutaneous GLP-2

Treatment:

Drug: GLP-2