Effect of the Intensity of Continuous Renal Replacement Therapy

Zhejiang University

Status: Completed

Conditions: Optimal Intensity of Renal Replacement Therapy on Sepsis Patients

Treatments: Other: high volume hemofiltration; Other: extra high volume hemofiltration

Study type: Interventional

Funder types: Other

Identifiers

NCT01251081

VHVHF

Details and patient eligibility

About

In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.

Enrollment: 280 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

met at least one of the following criteria: oliguria (urine output less than 100 mL in a 6 h period and unresponsive to fluid resuscitation), serum potassium concentration more than 6.5 mmol/L, severe acidemia (pH < 7.2), serum creatinine more than 250 µmol/L, or presence of severe organ edema (e.g. pulmonary edema).

Exclusion criteria

• were presence of a malignant tumor, chronic renal insufficiency (serum creatinine >133 µmol/L), or receiving any kind of renal replacement therapy before randomization.

Trial design

280 participants in 2 patient groups

extra high volume hemofiltration

Experimental group

Description:

extra high volume hemofiltration (85 mL/kg/h, EHVHF)

Treatment:

Other: extra high volume hemofiltration

high volume hemofiltration

Sham Comparator group

Description:

high volume hemofiltration (50 mL/kg/h, HVHF)

Treatment:

Other: high volume hemofiltration