Effect of the Pneumoperitoneum on Dynamic Variables Delta PP and PVI During Trendelenburg Position.

CHU Brugmann University Hospital

Status and phase: Completed; Phase 2

Conditions: Surgery

Treatments: Device: PVI and deltaPP after trendelenburg position change

Study type: Interventional

Funder types: Other

Identifiers

NCT02709252

201134

Details and patient eligibility

About

Arterial pulse pressure variation induced by mechanical ventilation (ΔPP) is considered one of the best parameter to predict fluid responsiveness in patients under general anaesthesia. Pleth Variability Index (PVI) has been proposed as a less invasive alternative. However, the pneumoperitoneum has been recently seen suggested as a limitation to their interpretation. The aim of this observational study is to compare changes in ΔPP and PVI related to autotransfusion associated with a Trendelenburg manoeuver before and during laparoscopy in patients undergoing elective surgery.

Enrollment: 50 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• American Society of Anesthesiologists (ASA) score I-II
• scheduled for elective abdominal laparoscopic surgery
• with written informed consent
• more than 18 years
• Body Mass Index < 40 kg.m-2
• no supraventricular arrhythmias
• no heart failure with ejection fraction <25 %
• no peripheral vascular
• no severe respiratory disease
• no end stage renal failure (creatinine clearance <30ml/min).

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

50 participants in 1 patient group

Cohort

Experimental group

Description:

Only one cohort is included with comparisons of two different hemodynamic parameters

Treatment:

Device: PVI and deltaPP after trendelenburg position change