Effect of the Salbutamol on Mechanical Properties of Respiratory System

Rio de Janeiro State University

Status: Unknown

Conditions: Airway Obstruction; Smoking

Treatments: Drug: Salbutamol sulphate

Study type: Interventional

Funder types: Other

Identifiers

NCT01521572

CEP2927/2011HUPE (Other Identifier)

2927/2011

Details and patient eligibility

About

The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.

Full description

Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.

Enrollment: 200 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy individuals, smokers and patients with chronic obstructive pulmonary disease.

Exclusion criteria

• healthy subjects: no history of smoking respiratory infection and disease respiratory
• smokers and chronic obstructive pulmonary disease patients: asthma and other respiratory diseases.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

Salbutamol

Experimental group

Description:

Short-acting bronchodilator for use in humans released by the Ministry of Health, widely used worldwide for the treatment of chronic obstructive pulmonary disease.

Treatment:

Drug: Salbutamol sulphate