Effect of Thiamphenicol on EAAT2 and Other Biomarkers From Nasal Biopsied Tissue

Psyadon Pharma

Status and phase: Completed; Phase 1

Conditions: Healthy

Treatments: Drug: Thiamphenicol; Drug: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00958503

EAAT2 Biomarker

Details and patient eligibility

About

The purpose of this study is to determine if two-weeks of dosing with thiamphenicol is safe and is able to change the levels of certain pre-specified biomarkers in nervous tissue taken from the nasal passages.

Full description

Thiamphenicol has been proposed to increase the levels of the excitatory amino acid transporter 2 (EAAT2) in the nervous tissue. This study evaluated the ability of two weeks of treatment with thiamphenicol to increase EAAT2 in a nasal biopsy as a surrogate of brain nervous tissue.

Enrollment: 30 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal volunteers

Exclusion criteria

• less than 18 years
• older than 55 years

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Placebo

Treatment:

Drug: Placebo

Thiamphenicol

Active Comparator group

Description:

Active comparator

Treatment:

Drug: Thiamphenicol