Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

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Vanderbilt University

Status and phase

Completed
Phase 1

Conditions

Coronary Artery Disease

Treatments

Drug: Adenosine

Study type

Interventional

Funder types

Other

Identifiers

NCT01690884
120477

Details and patient eligibility

About

The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

Full description

The investigators will compare adenosine interstitial levels using a parallel design study with three groups of subjects. Forearm interstitial adenosine levels will be measured at baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the investigators will repeat the dialysate collections at baseline and after adenosine infusions.

Enrollment

28 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Subjects will be healthy volunteers, without significant pulmonary, cardiovascular gastrointestinal, hematological or renal diseases
  2. Not taking any regular medications
  3. Able to provide signed consent prior to study participation.

Exclusion criteria

  1. History of asthma
  2. Pregnancy
  3. Exposure to an investigational drug in the last 2 months.
  4. Known hypersensitivity to study medications

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

28 participants in 3 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
To determine if there is an increase in adenosine interstitial levels in the forearm.
Treatment:
Drug: Adenosine
Dipyridamole
Active Comparator group
Description:
To determine if there is an increase in adenosine interstitial levels in the forearm.
Treatment:
Drug: Adenosine
Ticagrelor
Experimental group
Description:
To determine if there is an increase in adenosine interstitial levels in the forearm.
Treatment:
Drug: Adenosine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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