Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

Vanderbilt University

Status and phase: Completed; Phase 1

Conditions: Coronary Artery Disease

Treatments: Drug: Adenosine

Study type: Interventional

Funder types: Other

Identifiers

NCT01690884

120477

Details and patient eligibility

About

The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

Full description

The investigators will compare adenosine interstitial levels using a parallel design study with three groups of subjects. Forearm interstitial adenosine levels will be measured at baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the investigators will repeat the dialysate collections at baseline and after adenosine infusions.

Enrollment: 28 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Subjects will be healthy volunteers, without significant pulmonary, cardiovascular gastrointestinal, hematological or renal diseases
2. Not taking any regular medications
3. Able to provide signed consent prior to study participation.

Exclusion criteria

1. History of asthma
2. Pregnancy
3. Exposure to an investigational drug in the last 2 months.
4. Known hypersensitivity to study medications

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 3 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

To determine if there is an increase in adenosine interstitial levels in the forearm.

Treatment:

Drug: Adenosine

Dipyridamole

Active Comparator group

Description:

To determine if there is an increase in adenosine interstitial levels in the forearm.

Treatment:

Drug: Adenosine

Ticagrelor

Experimental group

Description:

To determine if there is an increase in adenosine interstitial levels in the forearm.

Treatment:

Drug: Adenosine