Effect of Timing Progesterone Luteal Support on Embryo Transfer

Mansoura Integrated Fertility Center

Status and phase: Completed; Phase 4

Conditions: Embryo Transfer; Progesterone Luteal Support in ICSI

Treatments: Drug: Progesterone 100 IM/day

Study type: Interventional

Funder types: Other

Identifiers

NCT03040830

P4 luteal support and ET

Details and patient eligibility

About

The study aims to know whether starting progesterone luteal support in intra cytoplasmic sperm injection (ICSI) cycles on the day of ovum pickup affects the degree of difficulty of embryo transfer compared with starting luteal support on day of embryo transfer

Full description

Double blind Randomized Controlled Trial (RCT) : the clinicians and the patents were blinded of the allocation group.

A total of 137 embryo transfers were randomly allocated into either arm I (67 ) starting luteal support as daily IM injections of 100 mg prontogest on day of egg retrieval , or arm II (66) starting the same P4 dose on day of embryo transfer

Enrollment: 150 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• first ICSI trial, normal uterus, normal cervix, normal ovarian response ,easy mock transfer,patient consenting

Exclusion criteria

• age over 38, difficult mock transfer, low and high ovarian response, patient not consenting

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 2 patient groups

Egg retrieval arm

Experimental group

Description:

67 ICSI cases are started daily 100 mg IM prontogest on the day of egg retrieval until the day of pregnancy test.

Treatment:

Drug: Progesterone 100 IM/day

Embryo transfer arm

Active Comparator group

Description:

66 ICSI cases are started daily 100 mg IM prontogest on the day of embryo transfer until the day of pregnancy test.

Treatment:

Drug: Progesterone 100 IM/day