Effect of TMS on Neuropathic Pain for Patients With Sci

Ankara Etlik City Hospital

Status: Enrolling

Conditions: Neuropathic Pain; Spinal Cord Injury

Treatments: Device: active TMS; Device: sham TMS

Study type: Interventional

Funder types: Other

Identifiers

NCT07293780

AEŞH-EK-2025-102

Details and patient eligibility

About

The aim of this study is to evaluate the efficacy of rTMS targeting the anterior cingulate cortex, another stimulation site that may be effective in the treatment of neuropathic pain, and to compare it with motor cortex stimulation.

Enrollment: 39 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients for whom at least 12 months have passed since the date of the event
2. Patients who meet the International Pain Working Group's criteria for central neuropathic pain below the level of the lesion and who have had pain for at least 6 months
3. Patients aged 18-65
4. Pain not attributable to other causes such as rheumatological diseases or diabetes
5. Patients with VAS > 4 despite maximum dose of pharmacological agents (anticonvulsants, antidepressants, narcotics), exercise and physical therapy agents, taking into account renal function tests and other comorbidities

Exclusion criteria

1. History of epilepsy
2. Metallic implant in the scalp
3. Cochlear implant
4. Spinal cord stimulator
5. Pacemaker
6. Presence of psychiatric illness
7. Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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39 participants in 3 patient groups

active rTMS primer motor cortex

Active Comparator group

Treatment:

Device: active TMS

rTMS anterior cingulate gyrus

Experimental group

Treatment:

Device: active TMS

sham rTMS primer motor cortex

Sham Comparator group

Treatment:

Device: sham TMS