Effect of Topical Anesthesia on Patient's Pain Discomfort and Radial Artery Spasm in Transradial Catheterization

Phramongkutklao College of Medicine and Hospital

Status and phase: Unknown; Phase 4

Conditions: Radial Artery Spasm

Treatments: Drug: Placebo; Drug: Topical Anesthetic

Study type: Interventional

Funder types: Other

Identifiers

NCT03501212

PMK-2018

Details and patient eligibility

About

This study evaluate topical anaesthesia application for 30 minutes before tranradial catheterization during cardiac catheterization can reduce pain and decrease radial artery spasm

Full description

The incidence of Radial artery spasm (RAS) has varied from 5-30% RAS refers to friction between the artery and wires or guide catheters accompanied by a subjective feeling of pain.

EMLA anesthetic ointment (AO-Astra Zeneca) is an emulsion of lidocaine 2.5% and prilocaine 2.5% in a ratio of 1:1 by weight Previous study showed that EMLA cream can increase the success rate of femoral cannulation in children.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients age >18 years.
• Patients who was schedule to performed coronary angiogram

Exclusion criteria

Previous ipsilateral transradial approach Raynaud's syndrome ESRD History of sensitivity to local anesthetics Non-palpable redial pulse Abnormal Barbeau's test Local site infection Patient's refusal

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 2 patient groups, including a placebo group

Interventional

Active Comparator group

Description:

EMLA group layer of 2.5 gr EMLA cream (standard adult dose) was applied to both wrists

Treatment:

Drug: Topical Anesthetic

Placebo

Placebo Comparator group

Description:

Placebo cream was applied to both wrists

Treatment:

Drug: Placebo