Effect of Topical Application of Atorvastatin Gel Versus Hyaluronic Acid on Immediate Loading Dental Implant in Posterior Maxilla

Amira attia

Status: Active, not recruiting

Conditions: In Recent Years, There Has Been a Rise in the Use of Immediate Loading Protocols; Dental Implant Stability

Treatments: Procedure: implant surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT06976866

M0103023OS

Details and patient eligibility

About

Background: In recent years, there has been a rise in the use of immediate loading protocols; however, the complex anatomy of the posterior maxilla presents challenges. Currently, there is a lack of comparative studies assessing the effects of hyaluronic acid and atorvastatin gel on enhancing bone density in this region in conjunction with immediate loading. This study aimed to compare the effect of topical application of atorvastatin gel versus hyaluronic acid around immediately loaded dental implant that replacing missed maxillary posterior teeth.

Patients and methods: twenty one patients were chosen from the Outpatient Clinic in the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking implant placement. Patients were divided randomly and equally into three groups: group I (control group): 7 patients received implants without coating by any materials. Group II [Hyaluronic acid (HA) group]: 7 patients received implants coated with HA gel .Group III [atorvastatin (ATV) group]: 7 patients received implants coated with ATV gel. Clinical evaluation of implant stability was performed at the time of implant insertion and after 3 and 6 months postoperative. Also, peri-implant pocket depth (PPD) and modified sulcus bleeding index (mSBI) were evaluated. Radiographical evaluation of bone density (BD) was performed immediately and after 6 months postoperatively of implant loading using CBCT. All clinical and radiographic data were subjected to statistical analysis.

Enrollment: 21 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Inclusion criteria:

• patients with one or more missing maxillary posterior teeth
• age ranging from 18 to 45 years
• patient's cooperation
• motivation and good oral hygiene
• adequate occlusion (proper interarch space).

Exclusion criteria

• individuals with systemic or local diseases that are contraindicative of surgery or implant placement
• pregnant individuals
• individuals with any bone diseases that may impede bone healing
• smokers
• individuals who exhibit parafunctional habits like bruxism and clenching.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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21 participants in 3 patient groups

hyaluronic acid

Experimental group

Description:

\[Hyaluronic acid (HA) group\]: 7 patients received implants coated with HA gel .

Treatment:

Procedure: implant surgery

atorvastatin

Experimental group

Description:

\[atorvastatin (ATV) group\]: 7 patients received implants coated with ATV gel

Treatment:

Procedure: implant surgery

control

Experimental group

Description:

group I (control group): 7 patients received implants without coating by any materials.

Treatment:

Procedure: implant surgery