Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Teeth

University of Bern

Status: Completed

Conditions: Dental Trauma; Periodontal Regeneration; Pulpal Regeneration; Topical Tetracycline; Topical Dexamethasone; Avulsion

Treatments: Procedure: Dexamethasone; Procedure: Tetracycline

Study type: Observational

Funder types: Other

Identifiers

NCT03611920

KEK: 2016-00383

Details and patient eligibility

About

To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.

Full description

Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined.

Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.

Enrollment: 33 patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Avulsion of a permanent tooth
• Written informed consent

Exclusion criteria

• Extended dry period of more than 60 minutes

Trial design

33 participants in 2 patient groups

Tetracycline

Description:

Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation

Treatment:

Procedure: Tetracycline

Dexamethasone

Description:

Teeth were soaked in dexamethasone (60μ ml-1) for 20 minutes before replantation

Treatment:

Procedure: Dexamethasone