Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study

Duke University

Status: Completed

Conditions: Oxyneurogram Index; Sensory Nerve Conduction

Treatments: Device: tourniquet, sensory nerve conduction abnormality

Study type: Interventional

Funder types: Other

Identifiers

NCT01970839

Pro00048542

Details and patient eligibility

About

There are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application. There is some scientific evidence from animal studies demonstrating that prolonged tourniquet application can result in lack of oxygen supply to nerves, and subsequent nerve damage resulting in chronic pain. This theory has not been proven in humans. In this study the investigators will indirectly assess the evidence for abnormalities caused by tourniquet application on subjects' nerves using well established devices to determine the function of these nerves.

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults
• Over 18 years of age

Exclusion criteria

• Neurological disease
• Diabetes mellitus
• History of nerve injury
• Chronic pain
• Alcoholism
• Blood pressure measurements greater than 140/80 and infection in the monitored area

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Tourniquet, pain, nerve injury, sensory nerve function

Other group

Treatment:

Device: tourniquet, sensory nerve conduction abnormality