Effect of Training Intensity on Microvascular Function

Université Libre de Bruxelles

Status: Completed

Conditions: Hemodynamic Rebound; Vascular Remodeling; Sedentary Behavior

Treatments: Procedure: Percutaneous muscle biopsies of the vastus lateralis (quadriceps); Other: Measurement of the maximal oxygen uptake (VO2max); Other: Non-Invasive Cardiac Output Measurement (Innocor)

Study type: Interventional

Funder types: Other

Identifiers

NCT07237854

ULB

Details and patient eligibility

About

The aim of this trial is to investigate the effect of aerobic training intensity on muscle vascular function: continuous versus interval.

Full description

This trial will compare the hemodynamic effects of aerobic training on muscle microvascular function between participants randomly assigned to one of two groups: a continuous training group and an high-intensity interval training group.

All data concerning the primary and secondary outcomes will be obtained at the start and repeated at the end of 8 weeks aerobic training.

Enrollment: 25 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy female or male between 18 and 45 years
• Be sedentary
• Able to cycle
• Able to provide written informed consent

Exclusion criteria

• Have a pathology that may impact vascular function as :

  • cardiac pathology
  • pneumological pathology
  • metabolic pathology

• Smoke

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

Moderate-Intensity Continuous Training (MICT): 34 min at 65% maximal heart rate

Experimental group

Description:

Participants performed a 3-minute warm-up at 50% of their maximal heart rate (HRmax), as determined during baseline cardiopulmonary exercise testing (ergospirometry), followed by 40 minutes of continuous cycling at 65% of their VO₂max. Sessions were conducted three times per week for a total duration of 8 weeks.

Treatment:

Other: Non-Invasive Cardiac Output Measurement (Innocor)

Other: Measurement of the maximal oxygen uptake (VO2max)

Procedure: Percutaneous muscle biopsies of the vastus lateralis (quadriceps)

High-Intensity Interval Training (HIIT): 2x2 min at 65% and 90% of maximal heart rate

Experimental group

Description:

Participants performed a 3-minute warm-up at 50% of their maximal heart rate (HRmax), as determined during baseline cardiopulmonary exercise testing (ergospirometry). The main training protocol consisted of alternating 2-minute cycling bouts: 2 minutes at 65% HRmax followed by 2 minutes at 90% HRmax, repeated continuously for a total of 28 minutes. Sessions were conducted three times per week over an 8-week period.

Treatment:

Other: Non-Invasive Cardiac Output Measurement (Innocor)

Other: Measurement of the maximal oxygen uptake (VO2max)

Procedure: Percutaneous muscle biopsies of the vastus lateralis (quadriceps)