Effect of Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions

Chungbuk National University

Status: Completed

Conditions: Obesity

Treatments: Device: tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02362542

2014-02-014

Details and patient eligibility

About

The purpose of this study is to investigate the effect of Transcranial Direct Current Stimulation (tDCS) on appetite control related brain regions.

Full description

Transcranial direct current stimulation (tDCS) is emerging tool for brain modulation in a variety of clinical conditions. In addition, recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity.

The investigators aim to assess whether modulation of the dorsolateral prefrontal cortex (DLFPC) using tDCS, modifies behavioral response and brain activity while watching visually presented food cues in obese subjects.

Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.

Subjects will perform functional MRI experiments with visual food cues. Questionnaire with behavior measures, body compositions, blood tests will be performed.

Enrollment: 15 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 28 kg/m2

Exclusion criteria

• history of brain trauma, epilepsy, or other neurological problems

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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15 participants in 2 patient groups

Sham tDCS

Experimental group

Description:

Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.

Treatment:

Device: tDCS

Real tDCS

Experimental group

Description:

Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.

Treatment:

Device: tDCS