Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-ankle Acupuncture Theory on EC50 of Remifentanil Inhibiting Responses to Tracheal Intubation Under General Anesthesia

Naval Military Medical University

Status

Completed

Conditions

Perioperative Analgesia

General Anaesthesia

Treatments

Other: TENS-WAA

Other: non TENS-WAA

Study type

Interventional

Funder types

Other

Identifiers

NCT06748898

TENS-WAA

Details and patient eligibility

About

During endotracheal tube insertion under general anesthesia, sympathetic nerve activity increases, which leads to increased heart rate, increased blood pressure, and increased catecholamine levels in the blood. It is important for patients to maintain hemodynamic stability during anesthesia induction and ultimately mitigate the cardiovascular stress response associated with tracheal intubation.

Transcutaneous Electrical Nerve Stimulation based on Wrist-Ankle Acupuncture theory (TENS-WAA) is a non-invasive pain treatment method, It has the advantages of easy wearing, concentrated treatment site, safe treatment and needle-free. To date, due to the lack of large-scale clinical use of TENS-WAA, only a few studies have reported the use of TENS-WAA for postoperative pain rehabilitation, especially for perioperative pain management. The aim of this study is to evaluate the median effective dose (ED50) of TENS-WAA for remifentanil inhibiting responses to tracheal intubation under general anesthesia, and to provide a reliable basis for its clinical promotion.

Enrollment

60 patients

Sex

All

Ages

18 to 64 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged 18-64 years old;
ASA grade I-Ⅲ;
BMI≤30kg/m2.

Exclusion criteria

Patients predicted to have difficult airways or those experiencing unsuccessful intubation processes;
Individuals with psychiatric disorders, cognitive impairments, or other conditions that preclude cooperation;
Patients who have received acupuncture treatment within the past three months or are undergoing routine acupuncture therapy;
Individuals with a history of severe cardiovascular disease, hyperthyroidism, or asthma;
Patients with contraindications to transcutaneous electrical nerve stimulation (TENS), including those with pacemakers, metallic implants, allergies to surface electrodes, skin sensory disorders, skin lesions, scars, or unhealed adhesions.