Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study

Chang Gung University

Status: Unknown

Conditions: Transcutaneous Nerve Stimulation

Treatments: Device: "Enraf-Nonius" Muscle stimulator

Study type: Interventional

Funder types: Other

Identifiers

NCT02115841

102-2266A3

Details and patient eligibility

About

Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability. Forms of Stimulation included transcranial direct current stimulation(tDCS) and transcranial alternating stimulation(tACS). tDCS had been proved the effect of cortical excitability modulation. The polarization effect of direct current stimulation can modulation specific brain area and enhance motor performance. tACS was still controversial about the effect on cortical excitability. Previous study show that the frequency dependent excitatory or inhibitory effect on cortex. The possible mechanism was to affect brain oscillation status by provided different frequency of stimulation. Transcutaneous nerve stimulation (TENS) was common used on management of chronic pain. Peripheral nerve stimulation can enhance pain or sensory evoked potential was noted. Effect of low frequency TENS on central nervous is unknown.

Enrollment: 48 estimated patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Health Adult

Trial design

48 participants in 2 patient groups

E1

Experimental group

Description:

Experiment 1 will measure the cortical excitability change after TENS intervention.

Treatment:

Device: "Enraf-Nonius" Muscle stimulator

E2

Experimental group

Description:

Experiment 2 will measures implicit sequential motor task performance and cortical hemodynamic response using near infrared spectroscopy (NIRS) during motor execution. Cortical excitability will also be measured contemporary

Treatment:

Device: "Enraf-Nonius" Muscle stimulator