Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

Capital Medical University

Status: Enrolling

Conditions: Liver Transplantation; End Stage Liver DIsease

Treatments: Diagnostic Test: blood sample; Biological: fresh frozen plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT04107883

LX-2019-LT-1

Details and patient eligibility

About

To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Child A/B cirrhosis
• patients who undergo the first OLT
• Informed and consented
• complete follow-up
• cooperate with treatment

Exclusion criteria

• re-transplant
• combined liver and other organ transplantation
• BMI≥30Kg/m2
• patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion
• acute liver failure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

control group

Experimental group

Description:

perform artificial colloidal solution transfusion during anhapetic phase.

Treatment:

Diagnostic Test: blood sample

anhapetic group

Experimental group

Description:

Perform plasma transfusion during anhapetic phase.

Treatment:

Biological: fresh frozen plasma

Diagnostic Test: blood sample