Effect of Transjugular Intrahepatic Portosystemic Shunt on Gut Microbiota in Cirrhotic Patients

Sichuan University

Status: Unknown

Conditions: Hepatic Encephalopathy; Cirrhosis; Acquired Portal-systemic Shunt Due to Cirrhosis

Study type: Observational

Funder types: Other

Identifiers

NCT02427906

WCH-2014-151 (Other Identifier)

2014-151

Details and patient eligibility

About

The purpose of this study is to determine the effect of transjugular intrahepatic portosystemic shunt on gut microbiota and associated inflammatory factors in cirrhotic patients.

Full description

Cirrhosis is associated with qualitative and quantitative changes in the gut microbiota that can potentiate disease progression and complications such as hepatic encephalopathy (HE) and infections. Dysbiosis or altered gut microbiota, due to decreased autochthonous or commensal taxa, has been found in stool and colonic mucosa in cirrhotic patients, which is in turn linked with disease severity and systemic inflammation.

TIPS can decompress the hypertensive portal vein,so that the intestinal congestion can be decrease too. Hence we summarize that TIPS may have effect on gut microbiota and associated inflammatory factors in cirrhotic patients.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cirrhotic patients who received TIPS;
• Treatment-naive to TIPS and major operation involving liver such as surgical shunt, hepatic resection and liver transplantation)

Exclusion criteria

• Uncontrolled infection or sepsis;
• Hepatobiliary or pancreatic malignancy or biliary obstruction;
• Vital organ dysfunction;
• Administration of antibiotics (after TIPS and 2 weeks before TIPS);
• Cachexia;
• Pregnant or breeding women

Trial design

50 participants in 2 patient groups

TIPS group

Description:

patients who have transjugular intrahepatic portosystemic shunt

Non-TIPS group

Description:

patients who have endoscopic variceal ligation