Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

Sichuan University

Status: Completed

Conditions: Hepatopulmonary Syndrome

Treatments: Procedure: Transjugular intrahepatic portosystemic shunt

Study type: Observational

Funder types: Other

Identifiers

NCT02148536

WCH-2014-034

Details and patient eligibility

About

To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of cirrhosis
• Alveolar-arterial oxygen gradient ≥ 15 mm Hg (≥ 20 mm Hg for age > 64 years)
• Positive contrast-enhanced echocardiography

Exclusion criteria

• Age of less than 18 years
• Intrinsic cardiopulmonary disease
• Malignancy
• Active infection
• Pregnancy
• Previous shunt therapy
• Refusal to participate

Trial design

64 participants in 1 patient group

HPS-TIPS group

Treatment:

Procedure: Transjugular intrahepatic portosystemic shunt