Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery

Capital Medical University

Status: Unknown

Conditions: Colorectal Neoplasms; Aged

Treatments: Drug: Saline; Drug: Dexmedetomidine; Procedure: Transversus abdominis plane block using ropivacaine; Procedure: Transversus abdominis plane block using saline

Study type: Interventional

Funder types: Other

Identifiers

NCT04516174

wys20200731

Details and patient eligibility

About

To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of dexmedetomidine. The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.

Enrollment: 180 estimated patients

Sex: All

Ages: 65 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 65-80 years,regardless of gender
• American Society of Anesthesiologists physical status I-III
• Undergoing elective radical resection of colorectal cancer
• Sign informed consent

Exclusion criteria

• Could not cooperate to complete the pain VAS evaluation
• Could not cooperate to complete the cognitive function assessment

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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180 participants in 2 patient groups, including a placebo group

Dex+TAPB group

Experimental group

Description:

Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation.

Treatment:

Procedure: Transversus abdominis plane block using ropivacaine

Drug: Dexmedetomidine

Control group

Placebo Comparator group

Description:

Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation.

Treatment:

Procedure: Transversus abdominis plane block using saline

Drug: Saline