Effect of Trendelenburg Positioning on Anesthesia-Induced Hypotension in Elderly Patients

University of Chinese Academy Sciences

Status: Not yet enrolling

Conditions: Hypotension on Induction; Old Age

Treatments: Other: Supine Horizontal Position; Other: Trendelenburg position

Study type: Interventional

Funder types: Other

Identifiers

NCT06968091

IRB-2025-478

Details and patient eligibility

About

This study investigated the effect of Trendelenburg position on preventing post-induction hypotension in elderly patients undergoing abdominal surgery with general anesthesia. The patients will receive the 10° Trendelenburg position or supine position during anesthesia induction. The primary outcome is the area under a mean arterial pressure (MAP) below 65 mm Hg within the first 15 minutes during anesthesia induction.

Enrollment: 168 estimated patients

Sex: All

Ages: 65 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 65-90 years
• scheduled for abdominal surgery with general anesthesia
• expected to have continuous radial arterial pressure monitoring
• American Society of Anesthesiologists (ASA) physical status I to III

Exclusion criteria

• contraindications or failure of radial arterial catheterization
• expected possible difficult airway
• non-sinus rhythm
• increased intracranial pressure
• patients at high risk of regurgitation or aspiration
• inability to provide consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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168 participants in 2 patient groups, including a placebo group

The Trendelenburg Position Group

Experimental group

Treatment:

Other: Trendelenburg position

The Supine Horizontal Position Group

Placebo Comparator group

Treatment:

Other: Supine Horizontal Position