Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas

Zhejiang University

Status: Completed

Conditions: Carcinoma, Hepatocellular

Treatments: Procedure: transcatheter arterial chemoembolization

Study type: Observational

Funder types: Other

Identifiers

NCT05352204

PTHCC

Details and patient eligibility

About

Micronecrosis is a novel pathological feature of hepatocellular carcinoma (HCC). This study was aimed at evaluating the effect of tumor micronecrosis on postoperative transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinomas, and further exploring the value of micronecrosis for guiding TACE in HCC management.

Enrollment: 900 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• (1) pathologically confirmed HCC (2) achievement of R0 resection.

Exclusion criteria

• (1) simultaneous presence of other tumors ; (2) receipt of preoperative anti-tumoral treatments; (3) concurrent treatment with other antitumoral therapies in combination with TACE; (4) tumor necrosis that could be observed by gross examination; (5) a lack of necessary preoperative laboratory test results.

Trial design

900 participants in 2 patient groups

micronecrosis(+) group

Treatment:

Procedure: transcatheter arterial chemoembolization

micronecrosis(-) group