Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

Zulekha Hospitals

Status

Completed

Conditions

Gastric Reflux

Treatments

Drug: Neostigmine

Study type

Observational

Funder types

Other

Identifiers

NCT06687187

382/46

Details and patient eligibility

About

A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.

Full description

Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.

Enrollment

3 patients

Sex

All

Ages

20 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

patients with a GRV >120ml
a normal heart rateExclusion Criteria
absence of comorbidities such as diabetes and renal failure. exclusion Criteria:
Patients exhibiting new-onset arrhythmias or heart block
hypotension (systolic blood pressure less than 60 mmHg)
experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
patients with electrolyte imbalance
pregnant patients,