Effect of Two Different Solutions on Wound Healing in Pressure Injury

Mensure Turan

Status: Completed

Conditions: Wound Care; Wound Cleansing; Pressure Injuries

Treatments: Other: 0.1% polyhexanide Care; Other: 0.9 % NaCl Care

Study type: Interventional

Funder types: Other

Identifiers

NCT06718777

2023/39

Details and patient eligibility

About

Pressure injuries are a condition that reduces patients' quality of life, increases hospitalization time and healthcare costs. When accompanied by infection and complications, mortality increases. The primary goal in pressure injuries is to prevent their occurrence, but once the injury has occurred, it is to provide effective and appropriate care. It is known that 0.9% sodium chloride (NaCl) is used routinely in pressure ulcer care. In addition, if the effectiveness of 0.1% polyhexanide in pressure ulcer care is demonstrated, it may provide data for its use in wound care. For this purpose, the study was completed as a randomized controlled trial with 32 individuals in the 0.1% polyhexanide group and 31 individuals in the 0.9% NaCl group, totaling 63 individuals.

Full description

The European Pressure Ulcer Advisory Panel (EPUAP) and the National Pressure Ulcer Advisory Panel (NPUAP) defined pressure injury (PI) as "Local skin and/or subcutaneous tissue damage caused by pressure alone, or by a combination of pressure and shear, most often occurring over bony prominences". It has been stated that the prevalence of pressure ulcers varies between 0-72.5%, and that it is a condition that reduces the quality of life of patients, increases the length of hospital stay and health care costs. In particular, the accompanying infection and complications of PI cause increased mortality. The primary purpose of PIs is to prevent their occurrence and after the injury occurs, it is necessary to provide care with effective and appropriate methods. The determined method should have the feature that can contribute to wound healing. There are many products and methods with appropriate features that can be used in PIs. In addition to the wet-dry gauze dressing used in wound care from past to present, different care solutions are also used. 0.9% NaCl solutions are frequently used in wound care. Since 0.1% polyhexanide solution is also an effective antiseptic, we thought that its use in PI care would contribute to treatment management by determining its effect on wound healing.

Enrollment: 63 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over the age of 18 who have developed pressure injuries
• Patients who have received informed consent from themselves or their guardians

Exclusion criteria

• Patients with clotting problems
• Patients using corticosteroids
• Patients receiving additional medical treatment for wound care

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

63 participants in 2 patient groups

0.1% polyhexanide

Experimental group

Description:

0.1% polyhexanide solution was applied 3 times at 48-hour intervals for pressure ulcer care.

Treatment:

Other: 0.1% polyhexanide Care

0.9% NaCl

Experimental group

Description:

0.9% sodium chloride solution was applied three times at 48-hour intervals for pressure ulcer care.

Treatment:

Other: 0.9 % NaCl Care