Effect of Two Doses of Coenzyme Q10 on Seminal Fluid and Semen Antioxidant Status

University of Sumer

Status: Completed

Conditions: Male Infertility

Treatments: Dietary Supplement: Coenzyme Q10 400; Dietary Supplement: Coenzyme Q10 200

Study type: Interventional

Funder types: Other

Identifiers

NCT03850561

EC/2018/8878

Details and patient eligibility

About

The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.

Full description

The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Enrollment: 65 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of infertility of at least 12 months despite regular unprotected intercourse.

Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010

Exclusion criteria

• Azoospermia,
• Varicocele,
• Genital tract infection,
• Cryptorchidism,
• Testicular trauma or scrotal surgery,
• Endocrine disorder,
• Systemic illness,
• Smoking
• The presence of female factor

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 2 patient groups

Coenzyme Q10 200

Active Comparator group

Description:

Coenzyme Q10 200mg/day for 3 months

Treatment:

Dietary Supplement: Coenzyme Q10 200

Coenzyme Q10 400

Active Comparator group

Description:

Coenzyme Q10 400mg/day for 3 months

Treatment:

Dietary Supplement: Coenzyme Q10 400