Effect of Two Exercise Programs on Bone Strength and Architecture
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About
Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than exercises that load the joints, like weight lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for 6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be taken at the beginning and the end of the 6 month program. Period blood samples will be taken for future analysis of blood markers.
Enrollment
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Volunteers
Inclusion criteria
- non-smoker
- in generally good health
- not physically active (less than 60 minutes of purposeful exercise/week)
- able to travel to the exercise facility a minimum of 3 times/week
Exclusion criteria
- use of glucocorticoids
- abnormal resting EKG
- angina and/or evidence of acute myocardial ischemia during a treadmill test
- resting blood pressure above 150 mmHg systolic of 90 mmHg diastolic
- anti-resorptive drug use in the last 2 years
- initiation of treatments that could impact bone metabolism (diuretics, hormones, bine anabolic agents) in the prior 6 months
- dual-energy x-ray absorptiometry (DXA) t-score <+ -2.5 at the femoral neck and/or lumbar spine
- serum vitamin D concentration <20 ng/mL
- uncontrolled thyroid disease
- any contraindications to regular exercise
Trial design
Primary purpose
Allocation
Interventional model
Masking
48 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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